A novel approach for the prediction of species-specific biotransformation of xenobiotic/drug molecules by the human gut microbiota.

ABSTRACT: The human gut microbiota is constituted of a diverse group of microbial species harbouring an enormous metabolic potential, which can alter the metabolism of orally administered drugs leading to individual/population-specific differences in drug responses. Considering the large heterogeneous pool of human gut bacteria and their metabolic enzymes, investigation of species-specific contribution to xenobiotic/drug metabolism by experimental studies is a challenging task. Therefore, we have developed a novel computational approach to predict the metabolic enzymes and gut bacterial species, which can potentially carry out the biotransformation of a xenobiotic/drug molecule. A substrate database was constructed for metabolic enzymes from 491 available human gut bacteria. The structural propertie

SUBMITTER: Sharma AK 

PROVIDER: S-EPMC5575299 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature