Early gestational maternal low-protein diet diminishes hepatic response to fasting in young adult male mice.

ABSTRACT: Maternal low-protein (MLP) diet can lead to hepatic steatosis, which only develops with ageing. It is still unclear whether the young offspring show any signs of past exposure to prenatal adverse conditions. We hypothesized that early nutritional insult would first affect the dynamic responsiveness to nutritional challenges rather than the static state. We analyzed the transcriptome and metabolome profiles of the hepatic response to fasting/refeeding in young male mice offspring to identify changes induced by early gestational MLP diet. Restricted MLP exposure strictly to early gestation was achieved by the embryo transfer method. As a result, the fasting-induced upregulation of genes related to long-chain fatty acid metabolism and of stress response genes related to protein folding were s

SUBMITTER: Sato N 

PROVIDER: S-EPMC5575317 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature