Subthalamic beta dynamics mirror Parkinsonian bradykinesia months after neurostimulator implantation.

ABSTRACT:

Background

Exaggerated oscillatory activity in the beta frequency band in the subthalamic nucleus has been suggested to be related to bradykinesia in Parkinson's disease (PD). However, studies seeking correlations between such activity in the local field potential and motor performance have been limited to the immediate postoperative period, which may be confounded by a stun effect that leads to the temporary alleviation of PD deficits.

Methods

Local field potentials were recorded simultaneously with motor performance in PD patients several months after neurostimulator implantation. This was enabled by the chronic implantation of a pulse generator with the capacity to record and transmit local field potentials from deep brain stimulation electrodes. Specifically, we investig

SUBMITTER: Steiner LA 

PROVIDER: S-EPMC5575541 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature