Epithelial-to-Mesenchymal Transition and MicroRNAs in Lung Cancer.

ABSTRACT: Despite major advances, non-small cell lung cancer (NSCLC) remains the major cause of cancer-related death in developed countries. Metastasis and drug resistance are the main factors contributing to relapse and death. Epithelial-to-mesenchymal transition (EMT) is a complex molecular and cellular process involved in tissue remodelling that was extensively studied as an actor of tumour progression, metastasis and drug resistance in many cancer types and in lung cancers. Here we described with an emphasis on NSCLC how the changes in signalling pathways, transcription factors expression or microRNAs that occur in cancer promote EMT. Understanding the biology of EMT will help to define reversing process and treatment strategies. We will see that this complex mechanism is related to inflammation

SUBMITTER: Legras A 

PROVIDER: S-EPMC5575604 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature