Concerning the vitamin D reference range: pre-analytical and analytical variability of vitamin D measurement.

ABSTRACT: Unlike other vitamins, the vitamin D concentration in blood varies cyclically over the course of the year in relation to genetic (gender, ethnicity, polymorphisms) and environmental factors (sunlight exposure, diet, food-related or direct vitamin D supplementation, skin pigmentation). Although the major diagnostics manufacturers have recently developed improved automated 25-hydroxy vitamin D immunoassays, the intra- and inter-laboratory variability is still high (especially at low vitamin D concentrations) which might lead to incorrect vitamin D deficiency/insufficiency diagnosis. Moreover, despite recent efforts to standardize the assay and minimize its variability, the current bias for measured vitamin D concentrations is often still above the desirable ± 10% criterion. Because the impli

SUBMITTER: Ferrari D 

PROVIDER: S-EPMC5575654 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature