Viral Infection Identifies Micropeptides Differentially Regulated in smORF-Containing lncRNAs.

ABSTRACT: Viral infection leads to a robust cellular response whereby the infected cell produces hundreds of molecular regulators to combat infection. Currently, non-canonical components, e.g., long noncoding RNAs (lncRNAs) have been added to the repertoire of immune regulators involved in the antiviral program. Interestingly, studies utilizing next-generation sequencing technologies show that a subset of the >10,000 lncRNAs in the mammalian genome contain small open reading frames (smORFs) associated with active translation, i.e., many lncRNAs are not noncoding. Here, we use genome-wide high-throughput methods to identify potential micropeptides in smORF-containing lncRNAs involved in the immune response. Using influenza as a viral infection model, we performed RNA-seq and ribosome profiling to tra

SUBMITTER: Razooky BS 

PROVIDER: S-EPMC5575669 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature