Epiregulin is required for lung tumor promotion in a murine two-stage carcinogenesis model.

ABSTRACT: Adenocarcinoma accounts for ∼40% of lung cancer, equating to ∼88 500 new patients in 2015, most of who will succumb to this disease, thus, the public health burden is evident. Unfortunately, few early biomarkers as well as effective therapies exist, hence the need for novel targets in lung cancer treatment. We previously identified epiregulin (Ereg), an EGF-like ligand, as a biomarker in several mouse lung cancer models. In the present investigation we used a primary two-stage initiation/promotion model to test our hypothesis that Ereg deficiency would reduce lung tumor promotion in mice. We used 3-methylcholanthrene (initiator) or oil vehicle followed by multiple weekly exposures to butylated hydroxytoluene (BHT; promoter) in mice lacking Ereg (Ereg^-/- ) and wildtype controls (

SUBMITTER: Bauer AK 

PROVIDER: S-EPMC5575741 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature