Development of an Improved Standard Reference Material for Vitamin D Metabolites in Human Serum.

ABSTRACT: The National Institute of Standards and Technology (NIST) has developed Standard Reference Material (SRM) 972a Vitamin D Metabolites in Frozen Human Serum as a replacement for SRM 972, which is no longer available. SRM 972a was developed in collaboration with the National Institutes of Health's Office of Dietary Supplements. In contrast to the previous reference material, three of the four levels of SRM 972a are composed of unmodified human serum. This SRM has certified and reference values for the following 25-hydroxyvitamin D [25(OH)D] species: 25(OH)D₂, 25(OH)D₃, and 3-epi-25(OH)D₃. The value assignment and certification process included three isotope-dilution mass spectrometry approaches, with measurements performed at NIST and at the Centers for Diseas

SUBMITTER: Phinney KW 

PROVIDER: S-EPMC5575745 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature