Gene Expression Profiling of Evening Fatigue in Women Undergoing Chemotherapy for Breast Cancer.

ABSTRACT: Moderate-to-severe fatigue occurs in up to 94% of oncology patients undergoing active treatment. Current interventions for fatigue are not efficacious. A major impediment to the development of effective treatments is a lack of understanding of the fundamental mechanisms underlying fatigue. In the current study, differences in phenotypic characteristics and gene expression profiles were evaluated in a sample of breast cancer patients undergoing chemotherapy (CTX) who reported low (n = 19) and high (n = 25) levels of evening fatigue. Compared to the low group, patients in the high evening fatigue group reported lower functional status scores, higher comorbidity scores, and fewer prior cancer treatments. One gene was identified as upregulated and 11 as downregulated in the high evening fatigu

SUBMITTER: Kober KM 

PROVIDER: S-EPMC5575784 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature