Measurement of Hypothalamic Glucose Under Euglycemia and Hyperglycemia by MRI at 3T.

ABSTRACT:

Purpose

To evaluate the feasibility of using a clinical magnetic resonance (MR) system and MR spectroscopy (MRS) to measure glucose concentration changes in the human hypothalamus, a structure central to whole-body glucose regulation.

Subjects and methods

A time series of MR spectra (semi-LASER, TE = 28 msec), localized to the bilateral hypothalamus (∼1.6 ml) were obtained at 3T in six healthy subjects at baseline (euglycemia) and during a ∼65-70-minute-long hyperglycemic clamp in 11-minute blocks with interleaved T₁ FLASH images to retrospectively assess head motion, and track changes in cerebrospinal fluid (CSF) partial volume. The LCModel was used to quantify the sum of glucose and taurine concentrations, [Glc+Tau], along with their associated Cramér-Rao lower

SUBMITTER: Joers JM 

PROVIDER: S-EPMC5575789 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature