NF-κB-regulated microRNA-574-5p underlies synaptic and cognitive impairment in response to atmospheric PM_2.5 aspiration.

ABSTRACT:

Background

PM_2.5 (particulate matter ≤ 2.5 μm) is one of the leading environmental risk factors for the global burden of disease. Whereas increasing evidence has linked the adverse roles of PM_2.5 with cardiovascular and respiratory diseases, limited but growing emerging evidence suggests that PM_2.5 exposure can affect the nervous system, causing neuroinflammation, synaptic dysfunction and cognitive deterioration. However, the molecular mechanisms underlying the synaptic and cognitive deficits elicited by PM_2.5 exposure are largely unknown.

Methods

C57BL/6 mice received oropharyngeal aspiration of PM_2.5 (1 and 5 mg/kg bw) every other day for 4 weeks. The mice were also stereotaxically injected with β-site amyloid precurso

SUBMITTER: Ku T 

PROVIDER: S-EPMC5575838 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature