Enzymatic Halogenation and Dehalogenation Reactions: Pervasive and Mechanistically Diverse.

ABSTRACT: Naturally produced halogenated compounds are ubiquitous across all domains of life where they perform a multitude of biological functions and adopt a diversity of chemical structures. Accordingly, a diverse collection of enzyme catalysts to install and remove halogens from organic scaffolds has evolved in nature. Accounting for the different chemical properties of the four halogen atoms (fluorine, chlorine, bromine, and iodine) and the diversity and chemical reactivity of their organic substrates, enzymes performing biosynthetic and degradative halogenation chemistry utilize numerous mechanistic strategies involving oxidation, reduction, and substitution. Biosynthetic halogenation reactions range from simple aromatic substitutions to stereoselective C-H functionalizations on remote carbon

SUBMITTER: Agarwal V 

PROVIDER: S-EPMC5575885 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature