Vitamin D receptor gene polymorphisms in association with diabetic nephropathy: a systematic review and meta-analysis.

ABSTRACT:

Background

A large amount of researches have demonstrated that vitamin D receptor (VDR) gene polymorphisms are associated with diabetic nephropathy (DN) risk in diabetes mellitus (DM) patients. Nevertheless, the results are inconclusive and inconsistent.

Methods

We screened PubMed, Embase, Chinese National Knowledge Infrastructure and Chinese Wanfang databases for those relevant studies updated in May 2016.

Results

7 studies involving 2564 subjects were recruited. We evaluated the genotypic and allelic differences between DN patients and DM controls. Overall analysis showed that no significant association was found among the ApaI, BsmI, FokI,TaqI gene polymorphisms and DN susceptibility in diabetic patients (all P values > 0.05). In the stratified analysis, TT genotyp

SUBMITTER: Yang L 

PROVIDER: S-EPMC5575903 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature