Serum cystatin C in youth with diabetes: The SEARCH for diabetes in youth study.

ABSTRACT:

Aims

We compared cystatin C in youth with versus without diabetes and determined factors associated with cystatin C in youth with type 1 diabetes (T1D) and type 2 diabetes (T2D).

Methods

Youth (ages 12-19years) without diabetes (N=544) were ascertained from the NHANES Study 2000-2002 and those with T1D (N=977) and T2D (N=168) from the SEARCH for Diabetes in Youth Study. Adjusted means of cystatin C concentrations were compared amongst the 3 groups. Next, we performed multivariable analyses within the T1D and T2D SEARCH samples to determine the association between cystatin C and race, sex, age, diabetes duration, HbA1c, fasting glucose, and BMI.

Results

Adjusted cystatin C concentrations were statistically higher in NHANES (0.85mg/L) than in either the T1D (0.75mg/L) o

SUBMITTER: Kanakatti Shankar R 

PROVIDER: S-EPMC5575920 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature