Gut microbiota is critical for the induction of chemotherapy-induced pain.

ABSTRACT: Chemotherapy-induced pain is a dose-limiting condition that affects 30% of patients undergoing chemotherapy. We found that gut microbiota promotes the development of chemotherapy-induced mechanical hyperalgesia. Oxaliplatin-induced mechanical hyperalgesia was reduced in germ-free mice and in mice pretreated with antibiotics. Restoring the microbiota of germ-free mice abrogated this protection. These effects appear to be mediated, in part, by TLR4 expressed on hematopoietic cells, including macrophages.

SUBMITTER: Shen S 

PROVIDER: S-EPMC5575957 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature