Brain Transforming Growth Factor-β Resists Hypertension Via Regulating Microglial Activation.

ABSTRACT:

Background and purpose

Hypertension is the major risk factor for stroke. Recent work unveiled that hypertension is associated with chronic neuroinflammation; microglia are the major players in neuroinflammation, and the activated microglia elevate sympathetic nerve activity and blood pressure. This study is to understand how brain homeostasis is kept from hypertensive disturbance and microglial activation at the onset of hypertension.

Methods

Hypertension was induced by subcutaneous delivery of angiotensin II, and blood pressure was monitored in conscious animals. Microglial activity was analyzed by flow cytometry and immunohistochemistry. Antibody, pharmacological chemical, and recombinant cytokine were administered to the brain through intracerebroventricular infusion. Mic

SUBMITTER: Li Y 

PROVIDER: S-EPMC5575981 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature