The three-dimensional genome organization of Drosophila melanogaster through data integration.

ABSTRACT:

Background

Genome structures are dynamic and non-randomly organized in the nucleus of higher eukaryotes. To maximize the accuracy and coverage of three-dimensional genome structural models, it is important to integrate all available sources of experimental information about a genome's organization. It remains a major challenge to integrate such data from various complementary experimental methods. Here, we present an approach for data integration to determine a population of complete three-dimensional genome structures that are statistically consistent with data from both genome-wide chromosome conformation capture (Hi-C) and lamina-DamID experiments.

Results

Our structures resolve the genome at the resolution of topological domains, and reproduce simultaneously both sets of

SUBMITTER: Li Q 

PROVIDER: S-EPMC5576134 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature