Differential gene expression in Anopheles stephensi following infection with drug-resistant Plasmodium yoelii.

ABSTRACT:

Background

The transmission of drug-resistant parasites by the mosquito may be influenced by the altered biological fitness of drug-resistant parasites and different immune reactions or metabolic change in the mosquito. At this point, little is known about the variations in mosquito immunity and metabolism when mosquitoes are infected with drug-resistant parasites. To understand the differential gene expression in Anopheles following infection with drug-resistant Plasmodium, we conducted a genome-wide transcriptomic profiling analysis of Anopheles stephensi following feeding on mice with drug-resistant or drug-sensitive P. yoelii, observed changes in gene expression profiles and identified transcripts affected by the drug-resistant parasite.

Results

To study the impact of dr

SUBMITTER: Zhang J 

PROVIDER: S-EPMC5576267 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature