PIM-1 mRNA expression is a potential prognostic biomarker in acute myeloid leukemia.

ABSTRACT:

Background

High expression of proviral integration site for Moloney murine leukemia virus-1 (PIM-1), a serine/threonine kinase, is associated with many cancers. The main purpose of this study were to investigate that the correlation between PIM-1 mRNA levels and clinicopathologic features and its clinical significance in acute myeloid leukemia (AML).

Methods

qRT-PCR was performed for 118 de novo AML and 20 AML complete remission patients and 15 normal individuals. All statistical analysis were performed using Graphpad Prism5 software.

Results

We observed that expression of PIM-1 mRNA was higher in AML patients than in healthy individuals and in complete remission AML patients (P = 0.0177). Further, high PIM-1 mRNA levels were more associated with high-risk FLT3+ AML p

SUBMITTER: Cheng H 

PROVIDER: S-EPMC5576275 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature