A targeted delivery strategy for the development of potent trypanocides.

ABSTRACT: A new drug delivery strategy was investigated for the development of potent anti-parasitic compounds against Trypanosoma brucei, the causative agent of African sleeping sickness. Thus, potent in vitro hexokinase inhibitors were rendered cytotoxic by appending a tripeptide peroxosomal targeting sequence that facilitated delivery of the molecular cargo to the appropriate organelle in the parasite.

SUBMITTER: Gordhan HM 

PROVIDER: S-EPMC5576345 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature