Improved protein structure reconstruction using secondary structures, contacts at higher distance thresholds, and non-contacts.

ABSTRACT:

Background

Residue-residue contacts are key features for accurate de novo protein structure prediction. For the optimal utilization of these predicted contacts in folding proteins accurately, it is important to study the challenges of reconstructing protein structures using true contacts. Because contact-guided protein modeling approach is valuable for predicting the folds of proteins that do not have structural templates, it is necessary for reconstruction studies to focus on hard-to-predict protein structures.

Results

Using a data set consisting of 496 structural domains released in recent CASP experiments and a dataset of 150 representative protein structures, in this work, we discuss three techniques to improve the reconstruction accuracy using true contacts - adding sec

SUBMITTER: Adhikari B 

PROVIDER: S-EPMC5576353 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature