Parkinson's disease is associated with DNA methylation levels in human blood and saliva.

ABSTRACT:

Background

Several articles suggest that DNA methylation levels in blood relate to Parkinson's disease (PD) but there is a need for a large-scale study that involves suitable population based controls. The purposes of the study were: (1) to study whether PD status is associated with DNA methylation levels in blood/saliva; (2) to study whether observed associations relate to blood cell types; and (3) to characterize genome-wide significant markers ("CpGs") and clusters of CpGs (co-methylation modules) in terms of biological pathways.

Methods

In a population-based case control study of PD, we studied blood samples from 335 PD cases and 237 controls and saliva samples from another 128 cases and 131 controls. DNA methylation data were generated from over 486,000 CpGs using the I

SUBMITTER: Chuang YH 

PROVIDER: S-EPMC5576382 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature