Vitamin D status during fetal life and childhood kidney outcomes.

ABSTRACT:

Background/objectives

Maternal vitamin D deficiency during pregnancy may influence offspring kidney health. We aimed to examine the associations of 25-hydroxyvitamin D (25(OH)D) blood levels during fetal life with kidney outcomes at school age.

Subjects/methods

This study was embedded in a population-based prospective cohort study among 4212 mother-child pairs. We measured maternal second trimester (18-25 weeks) and fetal cord blood (at birth) 25(OH)D levels. At a median age of 6.0 years, we measured children's combined kidney volume, glomerular filtration rate (eGFR) from creatinine and cystatin C serum levels, and microalbuminuria from albumin and creatinine urine levels.

Results

Of all mothers, 21.9% had severely deficient levels (25(OH)D <25.0 nmol/l), 25.7% had d

SUBMITTER: Miliku K 

PROVIDER: S-EPMC5576536 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature