Ontology highlight
ABSTRACT:
SUBMITTER: Daddacha W
PROVIDER: S-EPMC5576576 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Cell reports 20170801 8
DNA double-strand break (DSB) repair by homologous recombination (HR) is initiated by CtIP/MRN-mediated DNA end resection to maintain genome integrity. SAMHD1 is a dNTP triphosphohydrolase, which restricts HIV-1 infection, and mutations are associated with Aicardi-Goutières syndrome and cancer. We show that SAMHD1 has a dNTPase-independent function in promoting DNA end resection to facilitate DSB repair by HR. SAMHD1 deficiency or Vpx-mediated degradation causes hypersensitivity to DSB-inducing ...[more]