Gene Expression Analysis to Assess the Relevance of Rodent Models to Human Lung Injury.

ABSTRACT: The relevance of animal models to human diseases is an area of intense scientific debate. The degree to which mouse models of lung injury recapitulate human lung injury has never been assessed. Integrating data from both human and animal expression studies allows for increased statistical power and identification of conserved differential gene expression across organisms and conditions. We sought comprehensive integration of gene expression data in experimental acute lung injury (ALI) in rodents compared with humans. We performed two separate gene expression multicohort analyses to determine differential gene expression in experimental animal and human lung injury. We used correlational and pathway analyses combined with external in vitro gene expression data to identify both potential dri

SUBMITTER: Sweeney TE 

PROVIDER: S-EPMC5576585 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature