Study on molecular mechanism of ANOS1 promoting development of colorectal cancer.

ABSTRACT: Our main aim was to elucidate the molecular mechanism responsible for the development and metastasis of colorectal cancer. Furthermore, we also identified the key genes participating in this molecular mechanism and stimulating the progression of colorectal cancer. In our experiment, the ANOS1 gene showed up-regulated expression levels continuously, whereas the methylation level showed downregulated levels when the colorectal cancer progressed through the four clinical stages of development and metastasis. We obtained this information by analyzing the expression profile data and methylation data of ANOS1 gene in colorectal cancer. This phenomenon indicates that ANOS1 gene shows continuous activation during the progression of colorectal cancer. According to the results of survival analysis,

SUBMITTER: Qi L 

PROVIDER: S-EPMC5576693 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature