Reward-related neural activity and structure predict future substance use in dysregulated youth.

ABSTRACT:

Background

Identifying youth who may engage in future substance use could facilitate early identification of substance use disorder vulnerability. We aimed to identify biomarkers that predicted future substance use in psychiatrically un-well youth.

Method

LASSO regression for variable selection was used to predict substance use 24.3 months after neuroimaging assessment in 73 behaviorally and emotionally dysregulated youth aged 13.9 (s.d. = 2.0) years, 30 female, from three clinical sites in the Longitudinal Assessment of Manic Symptoms (LAMS) study. Predictor variables included neural activity during a reward task, cortical thickness, and clinical and demographic variables.

Results

Future substance use was associated with higher left middle prefrontal cortex activity,

SUBMITTER: Bertocci MA 

PROVIDER: S-EPMC5576722 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature