Self-organization process in newborn skin organoid formation inspires strategy to restore hair regeneration of adult cells.

ABSTRACT: Organoids made from dissociated progenitor cells undergo tissue-like organization. This in vitro self-organization process is not identical to embryonic organ formation, but it achieves a similar phenotype in vivo. This implies genetic codes do not specify morphology directly; instead, complex tissue architectures may be achieved through several intermediate layers of cross talk between genetic information and biophysical processes. Here we use newborn and adult skin organoids for analyses. Dissociated cells from newborn mouse skin form hair primordia-bearing organoids that grow hairs robustly in vivo after transplantation to nude mice. Detailed time-lapse imaging of 3D cultures revealed unexpected morphological transitions between six distinct phases: dissociated cells, cell aggregates, p

SUBMITTER: Lei M 

PROVIDER: S-EPMC5576784 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature