Zbtb7b engages the long noncoding RNA Blnc1 to drive brown and beige fat development and thermogenesis.

ABSTRACT: Brown and beige adipocytes convert chemical energy into heat through uncoupled respiration to defend against cold stress. Beyond thermogenesis, brown and beige fats engage other metabolic tissues via secreted factors to influence systemic energy metabolism. How the protein and long noncoding RNA (lncRNA) regulatory networks act in concert to regulate key aspects of thermogenic adipocyte biology remains largely unknown. Here we developed a genome-wide functional screen to interrogate the transcription factors and cofactors in thermogenic gene activation and identified zinc finger and BTB domain-containing 7b (Zbtb7b) as a potent driver of brown fat development and thermogenesis and cold-induced beige fat formation. Zbtb7b is required for activation of the thermogenic gene program in brown a

SUBMITTER: Li S 

PROVIDER: S-EPMC5576792 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature