High-speed photoacoustic microscopy of mouse cortical microhemodynamics.

ABSTRACT: We applied high-speed photoacoustic microscopy (PAM) for both cortical microenvironment studies and dynamic brain studies, with micrometer-level optical resolution and a millisecond-level cross-sectional imaging speed over a millimeter-level field of view. We monitored blood flow redistribution in mini-stroke mouse models and cerebral autoregulation induced by a vasoactive agent. Our results collectively suggest that high-speed PAM is a promising tool for understanding dynamic neurophysiological phenomena, complementing conventional imaging modalities.

SUBMITTER: Lin L 

PROVIDER: S-EPMC5576888 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature