One-Carbon Metabolism Biomarkers and Cognitive Decline in the Very Old: The Newcastle 85+ Study.

ABSTRACT:

Objectives

Although the biological rationale for the association between folate, vitamin B12, and homocysteine with cognitive function seems plausible, conflicting results have been reported. This study aimed to determine the associations between 1-carbon (1-C) metabolism biomarkers (folate, vitamin B12, and homocysteine), and cognitive impairment at baseline and the rate of cognitive decline over 5 years in the very old.

Design

The Newcastle 85+ Study was a prospective longitudinal study of people 85 years old and followed over 5 years in Northeast England.

Setting

Community-dwelling and institutionalized.

Participants

The analytical sample included 765 very old participants with 1-C metabolism biomarkers and cognitive measures.

Measurements

Global cogn

SUBMITTER: Mendonca N 

PROVIDER: S-EPMC5576913 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature