Distinct contributions of the fornix and inferior longitudinal fasciculus to episodic and semantic autobiographical memory.

ABSTRACT: Autobiographical memory (AM) is multifaceted, incorporating the vivid retrieval of contextual detail (episodic AM), together with semantic knowledge that infuses meaning and coherence into past events (semantic AM). While neuropsychological evidence highlights a role for the hippocampus and anterior temporal lobe (ATL) in episodic and semantic AM, respectively, it is unclear whether these constitute dissociable large-scale AM networks. We used high angular resolution diffusion-weighted imaging and constrained spherical deconvolution-based tractography to assess white matter microstructure in 27 healthy young adult participants who were asked to recall past experiences using word cues. Inter-individual variation in the microstructure of the fornix (the main hippocampal input/output pathway)

SUBMITTER: Hodgetts CJ 

PROVIDER: S-EPMC5576916 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature