IL233, A Novel IL-2 and IL-33 Hybrid Cytokine, Ameliorates Renal Injury.

ABSTRACT: CD4⁺Foxp3⁺ regulatory T cells (Tregs) protect the kidney during AKI. We previously found that IL-2, which is critical for Treg homeostasis, upregulates the IL-33 receptor (ST2) on CD4⁺ T cells, thus we hypothesized that IL-2 and IL-33 cooperate to enhance Treg function. We found that a major subset of Tregs in mice express ST2, and coinjection of IL-2 and IL-33 increased the number of Tregs in lymphoid organs and protected mice from ischemia-reperfusion injury (IRI) more efficiently than either cytokine alone. Accordingly, we generated a novel hybrid cytokine (IL233) bearing the activities of IL-2 and IL-33 for efficient targeting to Tregs. IL233 treatment increased the number of Tregs in blood and spleen and prevented IRI more efficiently than a mixture of

SUBMITTER: Stremska ME 

PROVIDER: S-EPMC5576940 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature