Autologous Mesenchymal Stem Cells Increase Cortical Perfusion in Renovascular Disease.

ABSTRACT: Atherosclerotic renovascular disease (RVD) reduces renal blood flow (RBF) and GFR and accelerates poststenotic kidney (STK) tissue injury. Preclinical studies indicate that mesenchymal stem cells (MSCs) can stimulate angiogenesis and modify immune function in experimental RVD. We assessed the safety and efficacy of adding intra-arterial autologous adipose-derived MSCs into STK to standardized medical treatment in human subjects without revascularization. The intervention group (n=14) received a single infusion of MSC (1.0 × 10⁵ or 2.5 × 10⁵ cells/kg; n=7 each) plus standardized medical treatment; the medical treatment only group (n=14) included subjects matched for age, kidney function, and stenosis severity. We measured cortical and medullary vol

SUBMITTER: Saad A 

PROVIDER: S-EPMC5576946 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature