Nomogram-based Prediction of Overall Survival in Patients with Metastatic Urothelial Carcinoma Receiving First-line Platinum-based Chemotherapy: Retrospective International Study of Invasive/Advanced Cancer of the Urothelium (RISC).

ABSTRACT:

Background

The available prognostic models for overall survival (OS) in patients with metastatic urothelial carcinoma (UC) have been derived from clinical trial populations of cisplatin-treated patients.

Objective

To develop a new model based on real-world patients.

Design, setting, and participants

Individual patient-level data from 29 centers were collected, including metastatic UC and first-line cisplatin- or carboplatin-based chemotherapy administered between January 2006 and January 2011.

Intervention

First-line, platinum-based, combination chemotherapy.

Outcome measurements and statistical analysis

The population was randomly split into a development and a validation cohort. Generalized boosted regression modelling was used to screen out irrelevant

SUBMITTER: Necchi A 

PROVIDER: S-EPMC5576985 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature