Massive transcriptome sequencing of human spinal cord tissues provides new insights into motor neuron degeneration in ALS.

ABSTRACT: ALS is a devastating and debilitating human disease characterized by the progressive death of upper and lower motor neurons. Although much effort has been made to elucidate molecular determinants underlying the onset and progression of the disorder, the causes of ALS remain largely unknown. In the present work, we have deeply sequenced whole transcriptome from spinal cord ventral horns of post-mortem ALS human donors affected by the sporadic form of the disease (which comprises ~90% of the cases but which is less investigated than the inherited form of the disease). We observe 1160 deregulated genes including 18 miRNAs and show that down regulated genes are mainly of neuronal derivation while up regulated genes have glial origin and tend to be involved in neuroinflammation or cell death. R

SUBMITTER: D'Erchia AM 

PROVIDER: S-EPMC5577269 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature