Influences of ethanol on the structure of toxic trans-crotonaldehyde in mitochondria coming from rat myocardium.

ABSTRACT: Inappropriate use of ethanol (EtOH) had led to noticeable health problems, but a beneficial phenomenon was found that EtOH displayed unique influences for toxic trans-crotonaldehyde (TCA) derived from mitochondrial lipid peroxidation. The influences of EtOH on the structure of TCA were systematically probed by UV-vis & Raman spectroscopy in the absence and presence of mitochondria, respectively. The maximum UV-vis peak at 301 nm of TCA was red shifted by hydroxyl (-OH) and methyl (-CH₃) of EtOH, respectively. Raman stretching band of aldehyde (-CH=O) of TCA (TCA-CH=O) was split by the -CH₃ of EtOH. The -CH₃ increased TCA-CH=O stretching frequency while the -OH induced it. The more exposed -OH, the less stretching frequency. The ectopic -CH₃ red s

SUBMITTER: Su Y 

PROVIDER: S-EPMC5577290 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature