Dynamics and implications of circulating anti-angiogenic VEGF-A₁₆₅b isoform in patients with ST-elevation myocardial infarction.

ABSTRACT: Angiogenesis is crucial to restore microvascular perfusion in the jeopardized myocardium in the weeks following reperfused ST-segment elevation myocardial infarction (STEMI). (VEGF)-A₁₆₅b, an anti-angiogenic factor, has been identified as a regulator of vascularization; however, it has not been previously implicated in acute myocardial infarction. We sought to investigate the dynamics of circulating VEGF-A₁₆₅b and its association with cardiac magnetic resonance-derived infarct size and left ventricular ejection fraction (LVEF). 50 STEMI patients and 23 controls were included. Compared with control individuals, serum VEGF-A₁₆₅b was elevated in STEMI patients prior to primary percutaneous coronary intervention (PCI). Following PCI, serum VEGF-A₁₆₅b

SUBMITTER: Hueso L 

PROVIDER: S-EPMC5577291 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature