Cerenkov Radiation-Induced Photoimmunotherapy with ¹⁸F-FDG.

ABSTRACT: Near-infrared photoimmunotherapy (NIR-PIT) is a new cancer treatment that combines the specificity of antibodies for targeting tumors with toxicity induced by photoabsorbers after irradiation with NIR light. A limitation of NIR-PIT is the inability to deliver NIR light to a tumor located deep inside the body. Cerenkov radiation (CR) is the ultraviolet and blue light that is produced by a charged particle traveling through a dielectric medium faster than the speed of light in that medium and is commonly produced during radioactive decay. Here, we demonstrate the feasibility of using CR generated by ¹⁸F-FDG accumulated in tumors to induce photoimmunotherapy. Methods: Using A431-luc cells, we evaluated the therapeutic effects of CR-PIT in vitro and in vivo using bioluminesce

SUBMITTER: Nakamura Y 

PROVIDER: S-EPMC5577626 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature