The neoepitope landscape in pediatric cancers.

ABSTRACT:

Background

Neoepitopes derived from tumor-specific somatic mutations are promising targets for immunotherapy in childhood cancers. However, the potential for such therapies in targeting these epitopes remains uncertain due to a lack of knowledge of the neoepitope landscape in childhood cancer. Studies to date have focused primarily on missense mutations without exploring gene fusions, which are a major class of oncogenic drivers in pediatric cancer.

Methods

We developed an analytical workflow for identification of putative neoepitopes based on somatic missense mutations and gene fusions using whole-genome sequencing data. Transcriptome sequencing data were incorporated to interrogate the expression status of the neoepitopes.

Results

We present the neoepitope landscape

SUBMITTER: Chang TC 

PROVIDER: S-EPMC5577668 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature