Copper-catalyzed oxidative C(sp³)-H/C(sp²)-H cross-coupling en route to carbocyclic rings.

ABSTRACT: Copper-catalyzed selective coupling of C(sp³)-H bonds with C(sp²)-H bonds has been developed. An aniline module was used as a directing group to generate an aminyl radical, which selectively cleaves the secondary and tertiary C(sp³)-H bonds via a 1,5-HAT process to forge six-membered carbocyclic rings.

SUBMITTER: Wang R 

PROVIDER: S-EPMC5577718 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature