The transcription factor Maf-S regulates metabolic resistance to insecticides in the malaria vector Anopheles gambiae.

ABSTRACT:

Background

Malaria control in Africa is dependent upon the use insecticides but intensive use of a limited number of chemicals has led to resistance in mosquito populations. Increased production of enzymes that detoxify insecticides is one of the most potent resistance mechanisms. Several metabolic enzymes have been implicated in insecticide resistance but the processes controlling their expression have remained largely elusive.

Results

Here, we show that the transcription factor Maf-S regulates expression of multiple detoxification genes, including the key insecticide metabolisers CYP6M2 and GSTD1 in the African malaria vector Anopheles gambiae. Attenuation of this transcription factor through RNAi induced knockdown reduced transcript levels of these effectors and significa

SUBMITTER: Ingham VA 

PROVIDER: S-EPMC5577768 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature