A subset of conserved mammalian long non-coding RNAs are fossils of ancestral protein-coding genes.

ABSTRACT:

Background

Only a small portion of human long non-coding RNAs (lncRNAs) appear to be conserved outside of mammals, but the events underlying the birth of new lncRNAs in mammals remain largely unknown. One potential source is remnants of protein-coding genes that transitioned into lncRNAs.

Results

We systematically compare lncRNA and protein-coding loci across vertebrates, and estimate that up to 5% of conserved mammalian lncRNAs are derived from lost protein-coding genes. These lncRNAs have specific characteristics, such as broader expression domains, that set them apart from other lncRNAs. Fourteen lncRNAs have sequence similarity with the loci of the contemporary homologs of the lost protein-coding genes. We propose that selection acting on enhancer sequences is mostly res

SUBMITTER: Hezroni H 

PROVIDER: S-EPMC5577775 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature