Uric acid promotes vascular stiffness, maladaptive inflammatory responses and proteinuria in western diet fed mice.

ABSTRACT:

Objective

Aortic vascular stiffness has been implicated in the development of cardiovascular disease (CVD) and chronic kidney disease (CKD) in obese individuals. However, the mechanism promoting these adverse effects are unclear. In this context, promotion of obesity through consumption of a western diet (WD) high in fat and fructose leads to excess circulating uric acid. There is accumulating data implicating elevated uric acid in the promotion of CVD and CKD. Accordingly, we hypothesized that xanthine oxidase(XO) inhibition with allopurinol would prevent a rise in vascular stiffness and proteinuria in a translationally relevant model of WD-induced obesity.

Materials/methods

Four-week-old C57BL6/J male mice were fed a WD with excess fat (46%) and fructose (17.5%) with or wi

SUBMITTER: Aroor AR 

PROVIDER: S-EPMC5577816 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature