Asymmetrically deployed actomyosin-based contractility generates a boundary between developing leg segments in Drosophila.

ABSTRACT: The formation of complex tissues from simple epithelial sheets requires the regional subdivision of the developing tissue. This is initially accomplished by a sequence of gene regulatory hierarchies that set up distinct fates within adjacent territories, and rely on cross-regulatory interactions to do so. However, once adjacent territories are established, cells that confront one another across territorial boundaries must actively participate in maintaining separation from each other. Classically, it was assumed that adhesive differences would be a primary means of sorting cells to their respective territories. Yet it is becoming clear that no single, simple mechanism is at play. In the few instances studied, an emergent theme along developmental boundaries is the generation of asymmetry i

SUBMITTER: Ly D 

PROVIDER: S-EPMC5577936 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature