Association of parathyroid hormone with 20-year cognitive decline: The ARIC study.

ABSTRACT:

Objective

We hypothesized that elevated parathyroid hormone (PTH) levels will be independently associated with 20-year cognitive decline in a large population-based cohort.

Methods

We studied 12,964 middle-aged white and black ARIC participants without a history of prior stroke who, in 1990-1992 (baseline), had serum PTH levels measured and cognitive function testing, with repeat cognitive testing performed at up to 2 follow-up visits. Cognitive testing included the Delayed Word Recall, the Digit Symbol Substitution, and the Word Fluency tests, which were summed as a global Z score. Using mixed-effects models, we compared the relative decline in individual and global cognitive scores between each of the top 3 quartiles of PTH levels to the reference bottom quartile. W

SUBMITTER: Kim SM 

PROVIDER: S-EPMC5577963 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature