Unusual Antioxidant Properties of 26S Proteasome Isolated from Cold-Adapted Organisms.

ABSTRACT: The oxidative challenge represents an important factor affecting the adaptive strategies in Antarctic fish, but their impact on the protein degradation machinery still remains unclear. The previous analysis of the first 26S proteasome from the Antarctic red-blooded fish Trematomus bernacchii, evidenced improved antioxidant functions necessary to counteract the environmental pro-oxidant conditions. The purpose of this work was to carry out a study on 26S proteasomes from the temperate red-blooded Dicenthrarcus labrax and the icefish Chionodraco hamatus in comparison with the isoform already described from T. bernacchii, to better elucidate the cold-adapted physiological functions of this complex. Therefore, the 26S isoforms were isolated and the complementary DNA

SUBMITTER: Gogliettino M 

PROVIDER: S-EPMC5577997 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature