Current whole-body MRI applications in the neurofibromatoses: NF1, NF2, and schwannomatosis.

ABSTRACT:

Objectives

The Response Evaluation in Neurofibromatosis and Schwannomatosis (REiNS) International Collaboration Whole-Body MRI (WB-MRI) Working Group reviewed the existing literature on WB-MRI, an emerging technology for assessing disease in patients with neurofibromatosis type 1 (NF1), neurofibromatosis type 2 (NF2), and schwannomatosis (SWN), to recommend optimal image acquisition and analysis methods to enable WB-MRI as an endpoint in NF clinical trials.

Methods

A systematic process was used to review all published data about WB-MRI in NF syndromes to assess diagnostic accuracy, feasibility and reproducibility, and data about specific techniques for assessment of tumor burden, characterization of neoplasms, and response to therapy.

Results

WB-MRI at 1.5T or 3.0T is

SUBMITTER: Ahlawat S 

PROVIDER: S-EPMC5578359 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature