CD74-Downregulation of Placental Macrophage-Trophoblastic Interactions in Preeclampsia.

ABSTRACT:

Rationale

We hypothesized that cluster of differentiation 74 (CD74) downregulation on placental macrophages, leading to altered macrophage-trophoblast interaction, is involved in preeclampsia.

Objective

Preeclamptic pregnancies feature hypertension, proteinuria, and placental anomalies. Feto-placental macrophages regulate villous trophoblast differentiation during placental development. Disturbance of this well-balanced regulation can lead to pathological pregnancies.

Methods and results

We performed whole-genome expression analysis of placental tissue. CD74 was one of the most downregulated genes in placentas from preeclamptic women. By reverse transcriptase-polymerase chain reaction, we confirmed this finding in early-onset (<34 gestational week, n=26) and late-onse

SUBMITTER: Przybyl L 

PROVIDER: S-EPMC5578411 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature