Metabolic profiling of polycystic ovary syndrome reveals interactions with abdominal obesity.

ABSTRACT:

Background

Polycystic ovary syndrome (PCOS) is a common reproductive disorder associated with metabolic disturbances including obesity, insulin resistance and diabetes mellitus. Here we investigate whether changes in the metabolic profile of PCOS women are driven by increased tendency to obesity or are specific features of PCOS related to increased testosterone levels.

Design and methods

We conducted an NMR metabolomics association study of PCOS cases (n=145) and controls (n=687) nested in a population-based birth cohort (n=3127). Subjects were 31 years old at examination. The main analyses were adjusted for waist circumference (WC) as a proxy measure of central obesity. Subsequently, metabolite concentrations were compared between cases and controls within pre-defined WC st

SUBMITTER: Couto Alves A 

PROVIDER: S-EPMC5578435 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature